Bevacizumab as a treatment for radiation necrosis following stereotactic radiosurgery for brain metastases: clinical and radiation dosimetric impacts
نویسندگان
چکیده
Background: Brain necrosis (RN) is a common radiotherapy sequela for brain metastases. Bevacizumab identified as therapeutic strategy RN. This study aimed to the clinical and radiobiological impacts on efficacy of in treating RN following stereotactic radiosurgery (SRS)
منابع مشابه
Bevacizumab as a treatment for radiation necrosis of brain metastases post stereotactic radiosurgery.
BACKGROUND Cerebral radiation necrosis (RN) is a difficult to treat complication of stereotactic radiosurgery (SRS) that can result in progressive neurologic decline. Currently, steroids are the standard of care treatment for brain RN despite their adverse effect profile and limited efficacy. The purpose of this study was to evaluate the treatment efficacy of cerebral RN to bevacizumab in patie...
متن کاملRecurrent radiation necrosis in the brain following stereotactic radiosurgery.
Harvard Medical School, Boston, Massachusetts Department of Neurosurgery, Dana-Farber/Brigham & Women’s Cancer Center, Boston, Massachusetts Department of Pathology, Dana-Farber/Brigham & Women’s Cancer Center, Boston, Massachusetts York Hospital Oncology, York, Maine Department of Medical Oncology, Dana-Farber/Brigham & Women’s Cancer Center, Boston, Massachusetts Department of Radiation Oncol...
متن کاملStereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial.
CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. OBJECTIVE To determine if WBRT combined with SRS results in improvements in survival, brain tumor control, functional preservation rate, and frequency of neur...
متن کاملRadiation Necrosis – A Growing Problem in a Case of Brain Metastases Following Whole Brain Radiotherapy and Stereotactic Radiosurgery
Stereotactic radiosurgery (SRS) provides excellent control in the treatment of brain metastases (BM). The use of newer, targeted and immunotherapy treatments have resulted in improved overall survival in patients even with an extensive metastatic disease. Hence, it is increasingly important to consider the potential for late toxicities like radiation-induced necrosis (RN) of the brain. We prese...
متن کاملManagement approach for recurrent brain metastases following upfront radiosurgery may affect risk of subsequent radiation necrosis
PURPOSE Many patients treated with stereotactic radiosurgery (SRS) alone as initial treatment require 1 or more subsequent salvage therapies. This study aimed to determine if commonly used salvage strategies are associated with differing risks of radiation necrosis (RN). METHODS AND MATERIALS All patients treated with upfront SRS alone for brain metastases at our institution were retrospectiv...
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ژورنال
عنوان ژورنال: Annals of palliative medicine
سال: 2021
ISSN: ['2224-5839', '2224-5820']
DOI: https://doi.org/10.21037/apm-20-2417